Gene/Protein | Genetic Alterations | Epigenetic Alterations | Expression/Distribution |
PTEN | Mutations/Deletion | Hypermethylation | Deactivation/Downregulation |
AKT | Activation/Overexpression | ||
PIK3CA | Mutation | ||
APC | Hypermethylation | Activation/Overexpression | |
b-Catenin | Mutation | Hypermethylation | Abnormal accumulations |
K-RAS | Mutation | ||
VEGF-C/VEGF-D | Activation/Overexpression | ||
VEGFR-2 | Activation/Overexpression | ||
STAT3/5 | Activation/Overexpression | ||
HER2/HER4 | Amplification | Activation/Overexpression | |
P53 | Mutation | ||
P16/INK4a | Mutation | Hypermethylation | Deactivation/downregulatin |
FGFR2 | Activation/Downregulation | ||
BCL2 | Mutation | ||
RASSF1A | Hypermethylation | ||
MGMT | Hypermethylation | ||
RARb2 | Hypermethylation | ||
14-3-3σ | Hypermethylation | ||
MLH1 | Hypermethylation | ||
Bax | Muation | ||
Cyclin D1 | Overexpression | ||
Survivin | Overexpression | ||
ER, PR | Overexpression | ||
EZH2 | Overexpression | ||
BM1 | Overexpression | ||
b-catenin | Overexpression | ||
E-cadherin | Hypermethylation | Overexpression | |
RUNX3 | Hypermethylation | ||
CDH13 | Hypermethylation | ||
MLH1 | Hypermethylation | ||
HOXa1, 9, 10, 11 | Hypermethylation | ||
HOXB5 | Hypermethylation | ||
HOXPX | Hypermethylation | ||
BAT25,BAT26, NR21, NR24, NR27 | MSI (Microsatellite instability) |