Gene/Protein

Genetic Alterations

Epigenetic Alterations

Expression/Distribution

PTEN

Mutations/Deletion

Hypermethylation

Deactivation/Downregulation

AKT

Activation/Overexpression

PIK3CA

Mutation

APC

Hypermethylation

Activation/Overexpression

b-Catenin

Mutation

Hypermethylation

Abnormal accumulations

K-RAS

Mutation

VEGF-C/VEGF-D

Activation/Overexpression

VEGFR-2

Activation/Overexpression

STAT3/5

Activation/Overexpression

HER2/HER4

Amplification

Activation/Overexpression

P53

Mutation

P16/INK4a

Mutation

Hypermethylation

Deactivation/downregulatin

FGFR2

Activation/Downregulation

BCL2

Mutation

RASSF1A

Hypermethylation

MGMT

Hypermethylation

RARb2

Hypermethylation

14-3-3σ

Hypermethylation

MLH1

Hypermethylation

Bax

Muation

Cyclin D1

Overexpression

Survivin

Overexpression

ER, PR

Overexpression

EZH2

Overexpression

BM1

Overexpression

b-catenin

Overexpression

E-cadherin

Hypermethylation

Overexpression

RUNX3

Hypermethylation

CDH13

Hypermethylation

MLH1

Hypermethylation

HOXa1, 9, 10, 11

Hypermethylation

HOXB5

Hypermethylation

HOXPX

Hypermethylation

BAT25,BAT26, NR21, NR24, NR27

MSI (Microsatellite instability)